Problem : Message delivery to the host failed while delivering to the remote domain for the following reason: The remote server did not respond to a connection attempt

Problem : Message delivery to the host failed while delivering to the remote domain for the following reason: The remote server did not respond to a connection attempt

I have WebSevrer installed MS windows server 2003 with SP2. SMTP mail sending is not working from our application asp.net. Application is able to generate the mails but all are going to QUEUE folder. Following error message found in event viewer.
“Message delivery to the host failed while delivering to the remote domain for the following reason: The remote server did not respond to a connection attempt”

Application is using CDOSYS message.

 

Solution : Message delivery to the host failed while delivering to the remote domain for the following reason: The remote server did not respond to a connection attempt

“SMTP could not connect to the DNS server ‘xxx.xx.xx.xx’. The protocol used was ‘UDP’. It may be down or inaccessible.”

I think the problem is you are using outside ISP DNS Servers. If you have configured the External DNS on your SMTP Virtual Server this will bypass the DNS settings you have on the Server itself. If you are
getting these messages I would suspect that at these times you’re not able to connect to the outside DNS Servers. It would be better to remove these settings from the Virtual Server and let the Windows DNS handle the lookups.